EDRF modulates renal hemodynamics during unilateral ureteral obstruction in the rat
نویسندگان
چکیده
منابع مشابه
Renin-angiotensin system and unilateral ureteral obstruction
Unilateral ureteral obstruction (UUO) is a clinical scenario that leads to obstructive nephropathy. UUO alters the expression of many mediators in the ipsilateral kidney. Renin-angiotensin system (RAS) is involved in UUO. Angiotensin II (Ang II) and angiotensin 1-7 (Ang 1-7) as the main arms of RAS influence kidney function which may alter by UUO. Ang II via Ang II receptor subtypes I (AT1R) ...
متن کاملCompensatory renal growth after unilateral ureteral obstruction.
Compensatory renal growth after unilateral ureteral obstruction. The accumulation of bulk renal protein, RNA and DNA was studied in mice during a 35-day period of accelerated renal growth in the kidney contralateral to that obstructed by acute ureteral ligation. Control mice were sham-operated and nonoperated. RNA was determined by the method of Monroe and Fleck, DNA after Ceriotti and protein ...
متن کاملBreviscapine prevents downregulation of renal water and sodium transport proteins in response to unilateral ureteral obstruction
Objective(s):Our recent report indicates that breviscapine play a protective role of the kidney by down-regulating transforming growth factor-β1(TGF-β1), α-smooth muscle actin (α-SMA) and alleviating interstitial fibrosis following unilateral ureteral obstruction (UUO). In this study, we investigate the effect of breviscapine on changes of renal water and sodium transport proteins in response t...
متن کاملThe effect of aliskiren on the renal dysfunction following unilateral ureteral obstruction in the rat.
PURPOSE To investigate the effect of blocking renin-angiotensin system by direct renin inhibition using aliskiren on the renal dysfunction following reversible unilateral ureteral obstruction (UO). METHODS Wistar rats underwent reversible left UO for 72 hours. Group-Alsk (n=12) received aliskiren (30 mg/kg/day) dissolved in water starting one day before creating UO and continued until the ter...
متن کاملDownregulation of renal aquaporins in response to unilateral ureteral obstruction.
The expression of aquaporin-2 (AQP2) is decreased in rats with bilateral ureteral obstruction (BUO) and unilateral ureteral obstruction (UUO). Therefore, the expression of additional renal aquaporins (AQP1-4) and phosphorylated AQP2 (p-AQP2), known to play a role in urinary concentration, was examined in a Wistar rat model with 24 h of UUO. In obstructed kidneys, immunoblotting revealed a signi...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1992
ISSN: 0085-2538
DOI: 10.1038/ki.1992.301